Intraarticular corticosteroids decrease synovial RANKL expression in inflammatory arthritis
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چکیده
منابع مشابه
Hyaluronan Inhibits Tlr-4-Dependent RANKL Expression in Human Rheumatoid Arthritis Synovial Fibroblasts
The Toll-like receptor (TLR) signaling pathway is activated in synovial fibroblast cells in patients with rheumatoid arthritis (RA). The receptor activator of nuclear factor-κB (RANK) and its ligand, RANKL, are key molecules involved in the differentiation of osteoclasts and joint destruction in RA. Hyaluronan (HA) is a major extracellular component and an important immune regulator. In this st...
متن کاملSynovial macrophage-osteoclast differentiation in inflammatory arthritis.
BACKGROUND Pathological bone resorption (marginal erosions and juxta-articular osteoporosis) by osteoclasts commonly occurs in rheumatoid arthritis (RA). OBJECTIVES To define the nature of the mononuclear precursor cells from which osteoclasts are formed in inflamed synovial tissues and to determine the cellular and humoral factors which influence osteoclast differentiation. METHOD Macropha...
متن کاملLocal administration of glucocorticoids decrease synovial citrullination in rheumatoid arthritis
Introduction: Protein citrullination is present in the rheumatoid synovium, presumably contributing to the perpetuation of chronic inflammation, in the presence of specific autoimmunity. As a result, the present study examines the possibility that effective anti rheumatic treatment will decrease the level of synovial citrullination. Methods: Synovial biopsies were obtained from 11 rheumatoid ar...
متن کاملRANK, RANKL and OPG in inflammatory arthritis and periprosthetic osteolysis.
Elucidation of the receptor activator of nuclear factor kappa B (RANK), its ligand (RANKL) and osteoprotegerin (OPG) as the final effectors of bone resorption has transformed our understanding of metabolic bone diseases and revealed novel therapeutic targets. Activation of the RANK-RANKL signaling pathway is directly responsible for dramatic focal erosions that are observed in inflammatory arth...
متن کاملExpression of FcRL4 defines a pro-inflammatory, RANKL-producing B cell subset in rheumatoid arthritis
OBJECTIVES The success of B cell targeting therapies has highlighted the importance of B cells in rheumatoid arthritis pathogenesis. We have previously shown that B cells in the RA synovium are capable of producing pro-inflammatory and bone-destructive cytokines including RANKL. Here we sought to characterise the nature and functional relevance of the RANKL-producing B cell subset in the RA syn...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 2006
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.21767